Clinical Study of Ligustrazine in Treating Alcohol Addiction
Alcohol Abuse · Arteriosclerosis
Enrolment: 400 · Results not recorded
Loading the evidence…
Drug · No ChEMBL entity retrieved for 'ligustrazine' or 'tetramethylpyrazine' by name search; left unresolved rather than matched to a related compound.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Alcohol Abuse · Arteriosclerosis
Enrolment: 400 · Results not recorded
Healthy
Enrolment: 16 · Results not recorded
Melasma
Enrolment: 10 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: 30% total body surface area scald injury
Ligustrazine lowered lung malondialdehyde, limited the fall in superoxide dismutase activity, reduced scald-induced MICA up-regulation and further increased Bcl-2, indicating protection of pulmonary tissue after scald injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Blunt chest trauma producing lung contusion
Ligustrazine significantly reduced apoptosis index and pulmonary oedema (p = 0.04), lowered plasma TNF-alpha (p = 0.03) and caspase-3 expression (p = 0.03) and raised the Bcl-2 to Bax ratio (p < 0.03) after blunt chest trauma.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.