Role of erythropoietin in prevention of amikacin-induced nephropathy.
RatChemical/toxinSprague-DawleyFemalen = 28 rats distributed equally into 4 groups (7 per group)Intraperitoneal2,000 IU/kgPretreatment before amikacin
Model: Amikacin-induced nephropathy (1.2 g/kg intraperitoneally)
Blood urea nitrogen rose from 13.1 plus or minus 0.4 mg/dL in saline controls to 26.6 plus or minus 3.9 mg/dL with amikacin (p < 0.01) and was significantly improved to 15.9 plus or minus 0.9 mg/dL with erythropoietin pretreatment, with marked reduction in histological tubular necrosis.
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