Preventing flow-metabolism uncoupling acutely reduces axonal injury after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMaleAdministered immediately following controlled cortical impact injury
Model: Controlled cortical impact injury
Acetazolamide globally doubled local cerebral blood flow above untreated injured rats at 3 h (p < 0.05) without significantly changing glucose metabolism, normalised the LCMRglc to LCBF ratio and significantly reduced beta-APP positive axon density at 24 h in most brain regions (p < 0.01), with onl…
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