Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax.
RatRadiationWAG/RijCmcrfemaleoral, in drinking watercaptopril 145-207 mg/m2/day; enalapril 19-28 mg/m2/day; fos…beginning 1 week after irradiation
Model: single 13 Gy X-irradiation to the whole thorax at 1.43 Gy/min
All three ACE inhibitors prevented the increase in lung collagen synthesis at 7 months and lung morphology supported protection against fibrosis. Captopril and enalapril, but not fosinopril, also reduced morbidity from acute pneumonitis.
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