Neuroprotection by urokinase plasminogen activator in the hippocampus.
MouseChemical/toxinC57BL/6 and 129 strain, including uPA-knockout miceintracerebral injectionprior administration, before kainate-induced seizures
Model: kainate-induced seizures causing excitotoxic hippocampal neuronal death, with in vitro exposure of primary hippocampal neurons to H2O2, zinc or excitotoxins
uPA-knockout mice were more vulnerable to kainate-induced neuronal death and uPA inhibition increased neuronal loss, whereas prior recombinant uPA significantly attenuated neuronal death.
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