Effectiveness and Safety of Early Lumbar Drainage in the Treatment of Ventricular Hemorrhage: the LD-IVH Randomized Controlled Trial
Intraventricular Hemorrhage · Cerebral Hemorrhage
Enrolment: 392 · Results not recorded
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Biologic · Urokinase-type plasminogen activator exogenous protein
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intraventricular Hemorrhage · Cerebral Hemorrhage
Enrolment: 392 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: kainate-induced seizures causing excitotoxic hippocampal neuronal death, with in vitro exposure of primary hippocampal neurons to H2O2, zinc or excitotoxins
uPA-knockout mice were more vulnerable to kainate-induced neuronal death and uPA inhibition increased neuronal loss, whereas prior recombinant uPA significantly attenuated neuronal death.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.