Protective effect of Danning tablet on acute livery injury with cholestasis induced by alpha-naphthylisothiocyanate in rats.
RatChemical/toxinWistarmaleintragastric3, 1.5 or 0.75 g/kg body weight per dayfor seven days before ANIT administration
Model: alpha-naphthylisothiocyanate (ANIT) 60 mg/kg intragastrically, inducing acute liver injury with cholestasis
Danning tablet 3 g/kg significantly reversed ANIT-induced changes in bile flow, serum liver enzymes and bilirubin and normalised hepatic antioxidant enzyme activities, with partial protection at 1.5 g/kg and no effect at 0.75 g/kg.
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