Production and radioprotective effects of pyrroloquinoline quinone.
MouseRadiationKMmale and female, evenly divided within each groupn = 20 mice per treatment group, with 10 sampled per group at e…oral2, 4 or 8 mg/kg PQQ in saline; nilestriol 10 mg/kg as posit…1 h before gamma irradiation
Model: single whole body cobalt-60 gamma irradiation at 236.05 cGy/min, 8 Gy for survival and 4 Gy for the haemopoiesis study
PQQ 4 mg/kg gave the best survival after 8 Gy, exceeding both irradiated controls and nilestriol, and accelerated recovery of white cells, reticulocytes and bone marrow cellularity after 4 Gy.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.