THERAPY DOSSIER · th-6ec1d5c2d51e

Pyrroloquinoline quinone (PQQ)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06431113 ↗PHASE3completed

Citicoline plus homotaurine plus PQQ (Neuprozin Mito) on pattern electroretinogram in open angle glaucoma

Glaucoma · Neuroprotection

Enrolment: 40 · Results not recorded

NCT07148726 ↗NAcompleted

PQQ supplementation on metabolic and physiological adaptation at rest and during submaximal exercise

Mitochondrial Biogenesis · Inflammation

Enrolment: 24 · Results not recorded

NCT05910047 ↗NAcompleted

Six-week hydrogen plus PQQ intake on mitochondrial biomarkers, brain metabolism and cognition in MCI

Age-associated Memory Impairment

Enrolment: 34 · Results not recorded

NCT07393464 ↗NAnot yet recruiting

PQQ add-on treatment for negative and cognitive symptoms in chronic schizophrenia

Schizophrenia · Cognitive Symptoms · Negative Symptoms

Enrolment: 70 · Results not recorded

NCT06748989 ↗NArecruiting

PQQ, GABA, caffeine and B-vitamin supplement on cognitive function in postmenopausal women

Cognitive Function and Memory

Enrolment: 70 · Results not recorded

NCT06548503 ↗NAcompleted

Silymarin, PQQ sodium salt and myricetin: alcohol levels and markers of oxidative stress

Oxidative Stress · Alcohol Drinking

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22272111 ↗2011Reported benefit

Production and radioprotective effects of pyrroloquinoline quinone.

MouseRadiationKMmale and female, evenly divided within each groupn = 20 mice per treatment group, with 10 sampled per group at e…oral2, 4 or 8 mg/kg PQQ in saline; nilestriol 10 mg/kg as posit…1 h before gamma irradiation

Model: single whole body cobalt-60 gamma irradiation at 236.05 cGy/min, 8 Gy for survival and 4 Gy for the haemopoiesis study

PQQ 4 mg/kg gave the best survival after 8 Gy, exceeding both irradiated controls and nilestriol, and accelerated recovery of white cells, reticulocytes and bone marrow cellularity after 4 Gy.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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