Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain.
MouseWoundICRmalen = 6 animals per group for behaviour; 8 culture wells or 6 tis…intraplantar injection around the incision; bath application in vitro1 or 10 micrograms intraplantar in the incision model; 0.1,…immediately after incision, or beginning 1 day after incision; co-injected with…
Model: plantar incision model of post-surgical pain, a 5 mm longitudinal incision through skin, fascia and muscle of the plantar hindpaw; also an intraplantar IL-6 hyperalgesic priming model
Local resveratrol dose-dependently reduced incision-induced mechanical allodynia and blocked the development of persistent nociceptive sensitisation, while activating AMPK and suppressing ERK and mTOR signalling in sensory neurons.
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