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PRECLINICAL PUBLICATION · 2012

Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22252860 ↗2012Reported benefit

Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

RatIschaemia-reperfusionIntestinal / mesentericWistar albinomalen = 30 rats in total, 10 per group across sham, ischaemia/reper…gastric gavage100 mg/kg3 days before ischaemia/reperfusion

Model: intestinal ischaemia/reperfusion, 1 h superior mesenteric artery ligation followed by 1 h reperfusion, causing acute lung injury

Curcumin lowered lung malondialdehyde, raised superoxide dismutase and glutathione peroxidase activity, reduced inducible nitric oxide synthase and increased surfactant protein D, and attenuated oedema, haemorrhage and inflammatory infiltration.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.