Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage.
MouseOtherC57BL/6, with mice having impaired autophagic responses
Model: acute focal cerebellar lesion causing axotomy and remote degeneration of precerebellar neurons
Cerebellar lesions activated autophagy in axotomised precerebellar neurons, and stimulating autophagy with rapamycin protected these neurons from degeneration and promoted functional recovery.
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