Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury.
RatSpinal cord injuryComplete transectionSprague-Dawleyfemalen = 30 rats in total, five groups of six animalsmotor-driven bicycle with hindpaws secured to foot pedalstwo 30 min sessions per day at 45 rpm separated by a 10 min…exercise began 5 days after transection
Model: complete low thoracic spinal cord transection, T9 laminectomy with removal of a 2 mm length of T10 cord by aspiration
Cycling raised BDNF and GDNF mRNA in whole cord, motoneurons and intermediate grey matter and increased HSP-27 and HSP-70 protein while attenuating caspase-7 and caspase-9 increases, but lowered NT-3 and NT-4 mRNA and had little effect in large DRG neurons.
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