THERAPY DOSSIER · th-62bfb89fbd80

Passive hindlimb cycling exercise

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03854214 ↗Injury indicationNAcompleted

Cortical functional connectivity as an early biomarker of recovery in SCI, FES cycling versus passive cycling

Spinal Cord Injuries

Enrolment: 14 · Results not recorded

NCT00245726 ↗Injury indicationNAcompleted

Lower extremity cycling with FES versus passive (motor assist) cycle in children with spinal cord injuries

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT07648173 ↗Injury indicationNArecruiting

Hybrid HIIT-FES cycling with passive range-of-motion leg exercise comparator in spinal cord injury

Spinal Cord Injuries

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22244304 ↗2011Mixed findings

Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury.

RatSpinal cord injuryComplete transectionSprague-Dawleyfemalen = 30 rats in total, five groups of six animalsmotor-driven bicycle with hindpaws secured to foot pedalstwo 30 min sessions per day at 45 rpm separated by a 10 min…exercise began 5 days after transection

Model: complete low thoracic spinal cord transection, T9 laminectomy with removal of a 2 mm length of T10 cord by aspiration

Cycling raised BDNF and GDNF mRNA in whole cord, motoneurons and intermediate grey matter and increased HSP-27 and HSP-70 protein while attenuating caspase-7 and caspase-9 increases, but lowered NT-3 and NT-4 mRNA and had little effect in large DRG neurons.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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