Body weight and leukocyte infiltration after an acute exercise-related muscle injury in ovariectomized mice treated with estrogen and progesterone.
MouseOtherC57BL/6ovariectomised females plus gonadal-intact females and malesn = 54 mice in total: 36 ovariectomised (9 per treatment group)…subcutaneous pellet implantation17-beta estradiol 0.05 mg pellet, progesterone 15 mg pellet…pellets inserted 15 days before injury, with the eccentric contraction protocol…
Model: eccentric contraction injury of the left plantarflexors by percutaneous tibial nerve stimulation (150 Hz, 4 V, 0.2 ms) with the ankle dorsiflexed through 26 degrees, 3 bouts of 150 trials
Short-term estrogen or progesterone did not change body weight or the number or area percentage of 7/4-positive leukocytes in injured muscle. The estrogen-only group showed a 2 to 3-fold greater mean 7/4 antigen area, suggesting altered leukocyte phenotype.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.