Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.
MouseTBIControlled cortical impactC57BL/6male1 mg/kg and 5 mg/kgbeginning after the injury
Model: murine controlled cortical impact traumatic brain injury and a murine intracerebral haemorrhage model
Rosuvastatin 1 mg/kg gave the greatest functional improvement after traumatic brain injury with less neuronal degeneration, reduced microgliosis and preserved CA3 neuronal density, while simvastatin 1 mg/kg was most effective after intracerebral haemorrhage independently of haemorrhage volume.
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