Caffeine prevents acute mortality after TBI in rats without increased morbidity.
RatTBIFluid percussionSprague-DawleyMalen = 42 male rats received fluid percussion injury in total; 15…Intraperitoneal25 mg/kgSingle injection within 1 minute after injury
Model: Lateral fluid percussion injury, 5 mm trephine at bregma -4.5 mm AP, +2.8 mm ML, 21-23 ms fluid pulse at peak pressure 1.97 +/- 0.02 ATM
Untreated severe injury produced 47 per cent acute mortality (7 of 15 rats) with prolonged apnoea in non-survivors. Caffeine given within 1 minute of injury prevented prolonged apnoea and completely prevented acute mortality in 8 treated rats. Neuromotor performance on Neuroscore and open field was…
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