Nanofibrous collagen nerve conduits for spinal cord repair.
RatSpinal cord injuryHemisection / partialSurgical implantation into the hemisection lesionElectrospun collagen fibres of diameter 208.2 +/- 90.4 nm f…Implanted at the time of acute injury
Model: Spinal cord hemisection model of acute spinal cord injury, with in vitro culture of primary rat astrocytes and dorsal root ganglia
Collagen nanofibres suppressed astrocyte proliferation and GFAP expression relative to two-dimensional controls at days 3 (p<0.05) and 7 (p<0.01), and aligned fibres elongated astrocytes (elongation factor greater than 4, p<0.01) and aligned neurite outgrowth along the fibre axis. In vivo, extensiv…
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