THERAPY DOSSIER · th-ad315a0ef743

Electrospun collagen nanofibre spiral tubular conduit (aligned or randomly oriented fibres)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22220714 ↗2012Reported benefit

Nanofibrous collagen nerve conduits for spinal cord repair.

RatSpinal cord injuryHemisection / partialSurgical implantation into the hemisection lesionElectrospun collagen fibres of diameter 208.2 +/- 90.4 nm f…Implanted at the time of acute injury

Model: Spinal cord hemisection model of acute spinal cord injury, with in vitro culture of primary rat astrocytes and dorsal root ganglia

Collagen nanofibres suppressed astrocyte proliferation and GFAP expression relative to two-dimensional controls at days 3 (p<0.05) and 7 (p<0.01), and aligned fibres elongated astrocytes (elongation factor greater than 4, p<0.01) and aligned neurite outgrowth along the fibre axis. In vivo, extensiv…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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