Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury.
MouseIschaemia-reperfusionOther / unspecifiedC57BL/6JFemaleDietaryAlternate-day fastingCommenced at 12 months of age and maintained for 6 months before the intraocula…
Model: Acute subischaemic retinal injury induced by intraocular pressure elevation, used as an optic nerve stress test
Older 18-month-old mice lost more inner retinal function after intraocular pressure challenge than younger adults. Dietary restriction improved recovery of inner retinal function after the challenge relative to ad libitum fed age-matched controls, and was associated with lower post-injury oxidative…
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