Analgesia or addiction?: implications for morphine use after spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMaleIntravenous self-administration, and systemic administration during conditioned place preference trainingAcute phase after contusion injury
Model: Contusion spinal cord injury
Contusion injury significantly increased conditioned place preference expression relative to sham and intact controls in the acute phase. Contused animals self-administered significantly less morphine than sham and intact controls, but the effect was dose-dependent: at a high concentration injured…
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