Promotion of recovery from thoracic spinal cord contusion in rats by stimulation of medullary raphe or its midbrain input.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntracranial deep brain stimulation (implanted microelectrode)Cathodal pulses at 8 Hz, 30 microamps via microelectrodeRaphe magnus stimulation started 1 to 2 hours after injury; parametric comparis…
Model: Moderate weight-drop contusion of the thoracic spinal cord at T8
Raphe magnus stimulation begun 1 to 2 hours after contusion gave enduring improvement in open-field, footprint and gridwalk performance, increasing with days of stimulation, and increased perilesional myelinated axons and serotonergic terminals. Starting 2 days after injury was better than 7 days o…
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