THERAPY DOSSIER · th-4ca08bc933c7

Intermittent electrical stimulation of the nucleus raphe magnus or the periaqueductal gray via implanted wireless stimulator

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22183979 ↗2011Reported benefit

Promotion of recovery from thoracic spinal cord contusion in rats by stimulation of medullary raphe or its midbrain input.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntracranial deep brain stimulation (implanted microelectrode)Cathodal pulses at 8 Hz, 30 microamps via microelectrodeRaphe magnus stimulation started 1 to 2 hours after injury; parametric comparis…

Model: Moderate weight-drop contusion of the thoracic spinal cord at T8

Raphe magnus stimulation begun 1 to 2 hours after contusion gave enduring improvement in open-field, footprint and gridwalk performance, increasing with days of stimulation, and increased perilesional myelinated axons and serotonergic terminals. Starting 2 days after injury was better than 7 days o…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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