Recovery of the injured external anal sphincter after injection of local or intravenous mesenchymal stem cells.
RatWoundLewisFemalen = 204 rats underwent laceration and repair, plus 20 uninjured…Direct intralesional injection into the injured sphincter, or intravenous injectionAt the time of sphincter repair
Model: Surgical laceration and repair of the external anal sphincter
Direct injection of mesenchymal stem cells improved contractile function at 21 days versus controls, with earlier TGF-beta1 and lysyl oxidase expression, increased collagen deposition and engraftment. Intravenous delivery did not improve function, and cells did not alter the transient inflammatory…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.