Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury.
RatSpinal cord injuryContusionLong-EvansFemalen = 50 female rats in total. Acute series n=9 (3 per group). Ch…Intraperitoneal bolus; subcutaneous osmotic mini-pump (Alzet 2001, 1.0 microlitre/h) for glibenclamide infusionAcute series: single bolus glibenclamide 10 micrograms/kg o…Acute series within 2 minutes of impact; chronic series beginning 3 hours after…
Model: Unilateral cervical spinal cord contusion at C7 by weight drop (10 g released from 30 mm) onto the left lateral cord after laminectomy, producing haemorrhagic contusion and high mortality
Both drugs reduced capillary fragmentation and progressive haemorrhagic necrosis acutely and prevented death, whereas vehicle mortality was very high. At 6 weeks modified BBB scores were similar, but glibenclamide gave significantly better rearing, rotarod, grip strength and tissue sparing than ril…
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