Study of dexamethasone, baicalin and octreotide on brain injury of rats with severe acute pancreatitis.
RatOtherSprague-DawleyMalen = Part 1: 90 severe acute pancreatitis rats in model control…After induction of severe acute pancreatitis, assessed at 3, 6 and 12 hours
Model: Surgically induced severe acute pancreatitis with secondary brain injury
Dexamethasone increased Bax and Bcl-2 and reduced NF-kappaB and brain pathological change versus model controls without changing the apoptotic index. Baicalin and octreotide also lowered brain NF-kappaB and raised Bcl-2, and baicalin raised Bax at 12 hours. Protection was attributed mainly to inhib…
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