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PRECLINICAL PUBLICATION · 2011

Effect of hypothermia on coagulatory function and survival in Sprague-Dawley rats exposed to uncontrolled haemorrhagic shock.

Rat / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22154303 ↗2011No effect reported

Effect of hypothermia on coagulatory function and survival in Sprague-Dawley rats exposed to uncontrolled haemorrhagic shock.

RatHaemorrhage/shockUncontrolledSprague-DawleyMalen = 32 male rats randomised into four groupsWhole-body coolingDuring the shock and resuscitation periods after splenic laceration

Model: Uncontrolled haemorrhagic shock induced by splenic laceration

Hypothermia alone did not alter coagulation capacity. In hypothermic haemorrhagic shock, clot formation time and maximal clot firmness fell and maximal clot firmness time was prolonged, indicating slower clotting, whereas clot firmness maximised rapidly under normothermic shock. Survival of hypothe…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.