THERAPY DOSSIER · th-76772b59af06

Induced hypothermia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01765218 ↗PHASE1/PHASE2terminated

Topiramate as an adjuvant to therapeutic hypothermia for infants with hypoxic ischaemic encephalopathy

Hypoxic Ischemic Encephalopathy

Enrolment: 34 · Results not recorded

NCT02030236 ↗NAunknown

CAERvest endothermic hypothermic device for core body cooling: safety and efficacy testing

Hypothermia

Enrolment: 30 · Results not recorded

NCT01996982 ↗NAterminated

Study of a new clinical device for reducing body core temperature

Hypothermia

Enrolment: 7 · Results not recorded

NCT01102153 ↗Phase not recordedcompleted

NSE as an outcome predictor of therapeutic hypothermia after survived sudden cardiac death

Cardiac Arrest · Hypothermia

Enrolment: 108 · Results not recorded

NCT00581581 ↗Phase not recordedcompleted

Long-term follow-up after head cooling for neonatal encephalopathy

Neonatal Encephalopathy

Enrolment: 62 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22154303 ↗2011No effect reported

Effect of hypothermia on coagulatory function and survival in Sprague-Dawley rats exposed to uncontrolled haemorrhagic shock.

RatHaemorrhage/shockUncontrolledSprague-DawleyMalen = 32 male rats randomised into four groupsWhole-body coolingDuring the shock and resuscitation periods after splenic laceration

Model: Uncontrolled haemorrhagic shock induced by splenic laceration

Hypothermia alone did not alter coagulation capacity. In hypothermic haemorrhagic shock, clot formation time and maximal clot firmness fell and maximal clot firmness time was prolonged, indicating slower clotting, whereas clot firmness maximised rapidly under normothermic shock. Survival of hypothe…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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