Intravesical chondroitin sulfate inhibits recruitment of inflammatory cells in an acute acid damage "leaky bladder" model of cystitis.
RatChemical/toxinSprague-Dawleyn = Two rats analysed per condition at each time pointIntravesical instillation retained for 20 minutes400 microlitres of 20 mg/mL chondroitin sulfate in 0.154 M…On the day following acid damage (24 hours after injury)
Model: Acute acid damage leaky bladder model: 400 microlitres of 10 mM hydrochloric acid instilled via an implanted bladder dome cannula for 10 minutes, aspirated and neutralised with 0.15 M sodium bicarbonate, removing most of the umbrella cell layer
Untreated mast cells rose four-fold at day 2 and six-fold at day 4 and neutrophils rose seven-fold and eleven-fold. Chondroitin sulfate significantly reduced mast cell (43% lower at day 4) and neutrophil (35% lower at day 4) recruitment to the suburothelial space with no change in CD45-positive lym…
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