Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice.
MouseIschaemia-reperfusionRenalC57BL/6JMaleIntraperitonealDexmedetomidine 25 micrograms/kg; atipamezole 250 microgram…Pre-treatment before ischaemia or post-treatment after reperfusion; atipamezole…
Model: Renal ischaemia-reperfusion by bilateral renal pedicle clamping for 45 minutes followed by 6 hours of reperfusion, producing remote acute lung injury
Renal ischaemia-reperfusion caused pulmonary injury with raised wet to dry ratio, myeloperoxidase activity and ICAM-1 and TNF-alpha mRNA. Both pre-treatment and post-treatment with dexmedetomidine reduced lung oedema, inflammation, myeloperoxidase activity and ICAM-1 and TNF-alpha expression. Atipa…
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