Protective effects of exogenous interleukin 18-binding protein in a rat model of acute renal ischemia-reperfusion injury.
RatIschaemia-reperfusionRenalSprague-DawleyMaleAdministered just before reperfusion
Model: Bilateral renal pedicle clamping ischaemia-reperfusion acute kidney injury
IL-18BP reduced tubular and peritubular capillary endothelial apoptosis, increased proliferation and capillary density, suppressed macrophage infiltration and inflammatory cytokines, raised VEGF and lowered thrombospondin 1 at 6, 24 and 72 h after reperfusion.
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