Evidence & regulatory context
- Mechanism
- Interleukin-18 inhibitor
- Target
- Interleukin-18
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- In trials, not approved
- ChEMBL max phase
- 3 / 4 (development scale, not regulatory approval)
- Synonyms
- Il-18bp; Interleukin-18-binding protein; Tadekinig alfa
- Note
- Not recorded
Clinical trials 3
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal Trial With Tadekinig Alfa (r-hIL-18BP) in Patients With IL-18 Driven Monogenic Autoinflammatory Conditions: NLRC4 Mutation and XIAP Deficiency
NLRC4-MAS · XIAP Deficiency
Enrolment: 15 · Results not recorded
Open-label, Multicenter, Dose-escalating Phase II Study to Investigate the Safety, Tolerability, and Early Signs of Efficacy of Subcutaneous Administrations of Tadekinig Alfa (IL-18BP) in Patients With Adult -Onset Still's Disease (AoSD) During 12 Weeks
Still's Disease, Adult-Onset
Enrolment: 23 · Results not recorded
Pilot, Open-Label Study Evaluating the Safety and Feasibility of Using Rescue Therapies for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome
CRS - Cytokine Release Syndrome · HLH
Enrolment: 10 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionRenalSprague-DawleyMaleAdministered just before reperfusion
Model: Bilateral renal pedicle clamping ischaemia-reperfusion acute kidney injury
IL-18BP reduced tubular and peritubular capillary endothelial apoptosis, increased proliferation and capillary density, suppressed macrophage infiltration and inflammatory cytokines, raised VEGF and lowered thrombospondin 1 at 6, 24 and 72 h after reperfusion.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
