Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure.
RatTBIUnspecifiedWistarMale3 or 12 h after traumatic brain injury
Model: Traumatic brain injury with acute ethanol pretreatment (3 g/kg) or dl-buthionine-(S,R)-sulfoximine pretreatment (100 mg/kg)
Ethanol pretreatment increased aquaporin-4 accumulation in astrocyte end feet and worsened oedema at 24 h, and acetazolamide raised the survival rate to 100 per cent while reducing brain oedema and aquaporin-4 in ethanol-pretreated rats.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.