Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats.
RatOtherSprague-DawleyMalen = 7 to 8 rats per groupIntramuscular10 to 30 mg/kg body weight68 min after the start of heat stress, at the end of heat exposure
Model: Heatstroke induced by exposing anaesthetised rats to 43 degrees Celsius for 68 min
Dextromethorphan at 30 mg/kg extended survival time to 193 to 209 min against 25 to 31 min in vehicle-treated heatstroke rats and exceeded MK-801 at 121 to 133 min, and reduced lung oedema, neutrophil infiltration, haemorrhage, pleurisy and lavage inflammatory and oxidative markers, whereas SA4503…
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