Delayed granulocyte colony-stimulating factor treatment promotes functional recovery in rats with severe contusive spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleSubcutaneousDelayed, subacute treatment beginning on post-contusion day 9
Model: Severe contusive spinal cord injury
Delayed G-CSF increased preserved spinal cord area, improved sensory and motor function, reduced myelin detachment and disruption with axonal sprouting, and lowered microglial and macrophage numbers, while brain-derived neurotrophic factor levels were comparable between groups.
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