PebbleAtlas
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PRECLINICAL PUBLICATION · 2011

A fragment of secreted Hsp90alpha carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22019588 ↗2011Reported benefit

A fragment of secreted Hsp90alpha carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

MouseWoundHairless and nude miceTopical applicationAfter wounding

Model: Acute excisional skin wounds and diabetic wounds

Topical F-5 peptide accelerated closure of both acute and diabetic wounds in mice substantially more than PDGF-BB, attributed to recruitment of both epidermal and dermal cells and to migration that resisted TGF-beta and hyperglycaemic inhibition.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.