THERAPY DOSSIER · th-b8cc19617392

F-5, a 115-amino-acid fragment of secreted Hsp90alpha

Biologic · ChEMBL NOT QUERIED: F-5 is a defined protein fragment of secreted Hsp90alpha with no INN/USAN name and no ChEMBL drug entry; not a registrable single chemical entity in ChEMBL drug space.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL NOT QUERIED: F-5 is a defined protein fragment of secreted Hsp90alpha with no INN/USAN name and no ChEMBL drug entry; not a registrable single chemical entity in ChEMBL drug space.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22019588 ↗2011Reported benefit

A fragment of secreted Hsp90alpha carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

MouseWoundHairless and nude miceTopical applicationAfter wounding

Model: Acute excisional skin wounds and diabetic wounds

Topical F-5 peptide accelerated closure of both acute and diabetic wounds in mice substantially more than PDGF-BB, attributed to recruitment of both epidermal and dermal cells and to migration that resisted TGF-beta and hyperglycaemic inhibition.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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