Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury.
MouseRadiationC57BL/6MaleSubcutaneous injection in vivo; added to culture medium in vitro15 mg/kg body weight in vivo, diluted in DMSO; in vitro add…Starting 24 h after total-body irradiation in vivo; 30 min before irradiation f…
Model: Caesium-137 gamma irradiation: 4 Gy to bone marrow mononuclear cells in long-term culture and 6.5 Gy sublethal total-body irradiation in vivo, dose rate 2.4 Gy/min
SB203580 inhibited radiation-induced p38 activation, reduced SA-beta-galactosidase positivity and p16INK4a expression, increased CFU-GM production more than threefold in irradiated long-term cultures, and partially restored haematopoietic stem and progenitor cell frequencies and clonogenic function…
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