PRECLINICAL PUBLICATION · 2011

Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats.

Rat / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Pyrrolidine dithiocarbamate (PDTC)

PMID 22011862 ↗2011Reported benefit

Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats.

RatChemical/toxinWistarMalen = 30 rats in three groups of 10

Model: Adriamycin (doxorubicin)-induced acute myocardial injury

Adriamycin increased NF-kappaB binding activity, myocardial apoptotic index and p53 expression, and all of these changes were inhibited by pyrrolidine dithiocarbamate.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.