Evidence & regulatory context
- Mechanism
- EXPLICIT SEARCHED NEGATIVE in ChEMBL: compound_search returned 0 hits for 'pyrrolidine dithiocarbamate', 'pyrrolidinedithiocarbamate', 'ammonium pyrrolidine dithiocarbamate' and 'pyrrolidine-1-carbodithioate'. A broad 'dithiocarbamate' query returned only DITIOCARB (CHEMBL961, diethyldithiocarbamate) and N-methyl-D-glucamine dithiocarbamate (CHEMBL4301787), neither of which is PDTC. No confident match; fields left empty rather than substituting a related dithiocarbamate.
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatChemical/toxinWistarMalen = 30 rats in three groups of 10
Model: Adriamycin (doxorubicin)-induced acute myocardial injury
Adriamycin increased NF-kappaB binding activity, myocardial apoptotic index and p53 expression, and all of these changes were inhibited by pyrrolidine dithiocarbamate.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
