17beta-estradiol protects the lung against acute injury: possible mediation by vasoactive intestinal polypeptide.
Guinea pigChemical/toxinInfusion into the pulmonary circulationBeginning 10 min before induction of injury
Model: Isolated perfused ventilated lung injured by paraquat oxidant stress, N-methyl-D-aspartate excitotoxicity or acute alveolar anoxia
Estradiol significantly attenuated lung injury in all three models, with paraquat producing the most severe injury, and rapidly stimulated vasoactive intestinal peptide mRNA expression in rat lung, suggesting partial mediation of the protection by VIP.
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