LPS-binding protein enables intestinal epithelial restitution despite LPS exposure.
RatEndotoxin/LPSAdded to culture medium in vitro; oral administration in the necrotising enterocolitis modelIncreasing concentrations, individual concentrations not st…Applied with lipopolysaccharide after wounding in vitro; given during the necro…
Model: Scrape wounding of immature rat intestinal epithelial cells (IEC-6) with lipopolysaccharide exposure in vitro, and a rodent model of necrotising enterocolitis in vivo
Lipopolysaccharide attenuated wound healing in immature intestinal epithelium and this was reversed at 24 h by higher concentrations of lipopolysaccharide-binding protein, which also normalised Toll-like receptor 4 expression, but lipopolysaccharide-binding protein had no effect on the development…
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