Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Burn · Endotoxin/LPS
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatBurnScaldSprague-DawleyMaleIn vitro cardiomyocyte co-cultureConcentrations 1 to 30 percent by volume (LPS 50 ug/mL)Cardiomyocytes isolated 24 h post-injury
Model: 30 percent TBSA scald burn with LPS challenge (cardiomyocytes studied in vitro)
High-dose rLBP restored cardiomyocyte sarcomere contractile function after burn and endotoxin exposure in vitro.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatEndotoxin/LPSAdded to culture medium in vitro; oral administration in the necrotising enterocolitis modelIncreasing concentrations, individual concentrations not st…Applied with lipopolysaccharide after wounding in vitro; given during the necro…
Model: Scrape wounding of immature rat intestinal epithelial cells (IEC-6) with lipopolysaccharide exposure in vitro, and a rodent model of necrotising enterocolitis in vivo
Lipopolysaccharide attenuated wound healing in immature intestinal epithelium and this was reversed at 24 h by higher concentrations of lipopolysaccharide-binding protein, which also normalised Toll-like receptor 4 expression, but lipopolysaccharide-binding protein had no effect on the development…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
