Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentials.
RatSpinal cord injuryContusionLewisFemalen = 21 rats (hypothermia n=10, control n=11); 3 rats per group…Systemic coolingTarget core temperature 32 plus or minus 0.5 degrees CelsiusInitiated approximately 2.0 h after injury
Model: Thoracic T8 contusion spinal cord injury with the NYU impactor, 12.5 mm weight drop
Hypothermia produced significantly higher postinjury somatosensory-evoked potential amplitudes with longer latencies, higher BBB scores immediately after injury and at 4 weeks, and greater tissue preservation on histology.
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