THERAPY DOSSIER · th-b853d45aac2c

Acute systemic hypothermia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02991690 ↗Injury indicationNArecruiting

Systemic Hypothermia in Acute Cervical Spinal Cord Injury - A Prospective, Multi-center Case Controlled Study

Spinal Cord Injury, Acute

Enrolment: 120 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22001581 ↗2012Reported benefit

Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentials.

RatSpinal cord injuryContusionLewisFemalen = 21 rats (hypothermia n=10, control n=11); 3 rats per group…Systemic coolingTarget core temperature 32 plus or minus 0.5 degrees CelsiusInitiated approximately 2.0 h after injury

Model: Thoracic T8 contusion spinal cord injury with the NYU impactor, 12.5 mm weight drop

Hypothermia produced significantly higher postinjury somatosensory-evoked potential amplitudes with longer latencies, higher BBB scores immediately after injury and at 4 weeks, and greater tissue preservation on histology.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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