Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage.
MouseOtherC57BL/6Male and femaleIntraperitoneal injectionOmeprazole 60 mg/kg; famotidine 30 mg/kgAcute blockade of acid secretion around the time of injury
Model: Laser-induced microscopic injury to the gastric epithelium of the exposed gastric corpus in anaesthetised mice, with luminal superfusion at pH 2, 3, 5 or 7
Epithelial repair varied with luminal pH, being unreliable at pH 2 and slower at pH 7; at luminal pH 3 and pH 7 omeprazole reduced maximal damage size and accelerated repair, and famotidine did the same at pH 7, with benefits extending beyond simply raising luminal or surface pH and without a rise…
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