Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain.
RatOtherSprague-DawleyMaleIntrathecal100, 200, 400 and 600 micrograms intrathecally; antagonist…
Model: Chronic constriction injury of the sciatic nerve for neuropathic pain, plus formalin-induced inflammatory nociception and tail flick and paw pressure tests for acute thermal and mechanical nociception
Intrathecal hypotaurine produced antinociception against thermal, mechanical and chemical nociception, and alleviated mechanical allodynia and thermal hyperalgesia in chronic constriction injury rats. These effects were completely reversed by intrathecal strychnine, and motor performance on the Rot…
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