Acute pulmonary injury induced by experimental muscle trauma.
RatWoundWistarn = 18 rats randomised into three groups of 6Intraperitoneal2 mg/kg body weight intraperitoneallyGiven 2 h before trauma and again 12 h after trauma
Model: Sharp section of the anterior thigh muscles just above the knee under tribromoethanol anaesthesia, preserving major vessels and nerves, producing distant acute lung injury
Twenty-four hours after thigh muscle transection there was a significant increase in lung neutrophil infiltration, myeloperoxidase activity and oedema, all reversed by dexamethasone treatment.
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