Sildenafil improves epicenter vascular perfusion but not hindlimb functional recovery after contusive spinal cord injury in mice.
MouseSpinal cord injuryContusionC57BL/6FemaleStarted immediately after injury
Model: Moderate contusive spinal cord injury in mice
Sildenafil increased spinal cord cyclic GMP concentrations and improved epicenter microvascular perfusion, but had no significant effect on angiogenesis at 7 days and no functional consequence for hindlimb locomotor recovery on Basso Mouse Scale or Treadscan analysis, indicating that acutely improv…
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