PRECLINICAL PUBLICATION · 2011

Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) hydrogel scaffold, prepared by bulk radical copolymerisation of 2-hydroxyethyl methacrylate, cholesterol methacrylate and ethylene dimethacrylate with ammonium oxalate crystals as porogen, with hydrolysed 2-[(methoxycarbonyl)methoxy]ethyl methacrylate introducing carboxyl groups to tune swelling and softness

PMID 21953978 ↗2011Reported benefit

Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.

RatSpinal cord injuryHemisection / partialWistarMaleImplanted into the spinal cord to bridge the hemisection cavityImplanted at the time of acute hemisection injury, with histological assessment…

Model: Acute spinal cord hemisection creating a cavity bridged by an implanted hydrogel; complemented by in vitro culture of rat mesenchymal stem cells on the scaffolds

The hydrogels supported in vitro adhesion and proliferation of rat mesenchymal stem cells, and at 4 weeks after implantation showed good incorporation into surrounding tissue with progressive connective tissue infiltration and ingrowth of neurofilaments, Schwann cells and blood vessels into the por…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.